Lupus in Women: Why It Affects Females More Often

According to the Lupus Research Alliance, 9 out of 10 diagnosed lupus cases occur in women. While the exact reasons for this are not fully understood, it is believed that a combination of genetic, hormonal, and environmental factors plays a significant role.

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The information provided in this article is for general informational purposes only and is not intended as medical advice. It should not be used as a substitute for professional diagnosis, treatment, or advice from a qualified healthcare provider. Reliance on any information provided in this article is solely at your own risk.

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Some research indicates that lupus is linked to high estrogen levels. This means that lupus occurs more frequently when a woman is on her menstrual cycle or is pregnant. Estrogen commonly enhances immune responses, which makes women more prone to autoimmune diseases. Women often report experiencing worsening symptoms of lupus during their menstrual cycle or pregnancy. This is due to the high levels of estrogen produced.

Women have two X chromosomes, while men have an X and a Y chromosome. Every female experiences something known as X chromosome inactivation, where one of the two X chromosomes is silenced by a molecule called Xist to prevent harmful effects of producing twice the amount of X-linked genes. Many proteins that attach to the Xist molecule, along with the Xist molecule itself, are known targets of autoantibodies, which could explain why lupus is more common in women.

Lupus is generally seen as a woman’s disease, so doctors may overlook symptoms of lupus in men and point them at another disease. This creates a huge gender gap and once again divides men and women’s healthcare into two rather than one. It is important to remember that while lupus in men is a rarer occurrence, male patients deserve the same care and advocacy from doctors, fellow warriors, and their community.

In conclusion, the reason why lupus is more commonly diagnosed in women is still unclear but is likely due to factors such as higher estrogen levels and genetics. Understanding these underlying reasons can help doctors diagnose and treat lupus more efficiently. It also sets a baseline for more effective research to be conducted on lupus prevention, medications, cures, and additional treatments for lupus.

Lupus and Women | OASH

What are the early signs of lupus in women? | Medical News Today

Recent Discoveries Shedding Light on Why Women Are at a Greater Risk for Lupus | Lupus Research Alliance